| Shougi 3 (Japan) | |
| Shrek - Fairy Tale Freakdown (USA) (En,Fr,De,Es,It) | |
| Shuma Baobei - Chao Mengmeng Fanji Zhan (Unlicensed, Chinese) | |
| Shuma Baobei - Hai Zhi Shen (Unlicensed, Chinese) | |
| Shuma Baobei - Huojian Bingtuan (Unlicensed, Chinese) | |
| Shutokou Racing, The (Japan) | |
| Simpsons, The - Night of the Living Treehouse of Horror (USA, Europe) | |
| Smurfs Nightmare, The (Europe) (En,Fr,De,Es) | |
| Smurfs Nightmare, The (USA) | |
| Snobo Champion (Japan) | |
| Snoopy Tennis (Europe) (En,Fr,De,Es,It,Nl) | |
| Snoopy Tennis (Japan) | |
| Snoopy Tennis (USA) (En,Fr,Es) | |
| Snow White and the Seven Dwarfs (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Snow White and the Seven Dwarfs (USA) | |
| SnowCross (Europe) (En,Fr,De,Es,It,Pt) | |
| Soccer Manager (Europe) (En,Fr,De,Es) | |
| Solomon (Japan) | |
| Sonic 7 | |
| Sonic Adventure 8 | |
| Soreike! Anpanman - 5-tsu no Tou no Ousama (Japan) | |
| Soreike! Anpanman - Fushigi na Nikoniko Album (Japan) | |
| Soukoban Densetsu - Hikari to Yami no Kuni (Japan) | |
| Soul Falchion (Unl) | |
| Soul Getter - Houkago Bouken RPG (Japan) | |
| South Park (Game Boy Color Prototype) | |
| Space Baby (The Firmament Baby) (Unl) | |
| Space Invaders (USA) | |
| Space Invaders X (Japan) | |
| Space Invasion (Europe) (Unl) | |
| Space Invasion & Karate Joe (Europe) (Unl) | |
| Space Marauder (USA) | |
| Space-Net - Cosmo Blue (Japan) | |
| Space-Net - Cosmo Red (Japan) | |
| Spacestation Silicon Valley (Europe) (En,Fr,De,Es,It,Nl,Sv) | |
| Spawn (USA) | |
| Speedy Gonzales - Aztec Adventure (USA) | |
| Spider-Man (France) | |
| Spider-Man (Japan) | |
| Spider-Man (USA, Europe) | |
| Spider-Man 2 - The Sinister Six (USA) | |
| Spirou Robbedoes - The Robot Invasion (Europe) (En,Fr,De,Es,It,Nl,Da) | |
| SpongeBob SquarePants - Legend of the Lost Spatula (USA) | |
| Spy vs. Spy (Europe) (En,Fr,De,Es,It,Nl,Sv) | |
| Spy vs. Spy (Japan) | |
| Spy vs. Spy (USA) | |
| Star Ocean - Blue Sphere (Japan) | |
| Star Wars - Yoda Stories (USA, Europe) | |
| Star Wars Episode I - Obi-Wan's Adventures (USA) | |
| Star Wars Episode I - Racer (USA, Europe) | |