| Crayon Shin-chan - Arashi o Yobu Nendororoon Daihenshin! (Japan) | |
| Crayon Shin-chan - Obaka Dainin Den - Susume! Kasukabe Ninja Tai! (Japan) | |
| Crayon Shin-chan - Shock Gahn! - Densetsu o Yobu Omake Daiketsusen!! (Japan) | |
| Crayon Shin-chan DS - Arashi o Yobu Nutte Crayoon Daisakusen! (Japan) | |
| Crazy Chicken - Star Karts (USA) (En,Fr,De,Es,It) | |
| Crazy Chicken Adventure - The Pharaoh's Treasure (USA) (En,Fr,De,Es,It) | |
| Crazy Chicken Carnival (Europe) (En,Fr,De,Es,It) | |
| Crazy Chicken Jump'n Run - Atlantis Quest (USA) (En,Fr,De,Es,It) | |
| Crazy Circus (Europe) (En,Fr,De,Es,It) | |
| Crazy Frog Collectables - Art School (Europe) (En,Fr,De,Es,It) | |
| Crazy Frog Racer (Europe) (En,Fr,De,Es,It) | |
| Crazy Machines (Europe) (En,Fr,De,Es,It) | |
| Crazy Machines (Germany) (En,De) | |
| Crazy Machines 2 (Europe) (En,Fr,De,Es,It) | |
| Crazy Pig (Europe) (En,Fr,De,Es,It,Nl) | |
| Crazy School Games (Europe) (En,Fr,De,Es,It) | |
| Crime Lab - Body of Evidence (Europe) (En,Es,It,Nl) (NDSi Enhanced) | |
| Crime Scene (Europe) (En,Fr,De,Es,It) | |
| Crime Scene (USA) (En,Fr,Es) | |
| Crimson Room (Japan) | |
| Croket! DS - Tenkuu no Yuusha-tachi (Japan) | |
| Cross Treasures (Japan) | |
| Crossword de Manabou! Chiri - Rekishi (Japan) | |
| Crossword DS + Sekai 1-shuu Cross (Japan) | |
| Crosswords - Cruciverba Italiani (Italy) | |
| CrossworDS (Europe) (En,Fr,De,Es,It) | |
| CrossworDS (USA) | |
| Cruciverba per DS (Italy) | |
| Cruise Line Tycoon (Europe) (En,Fr,De,Es,It,Nl) | |
| Crystal Mines (Europe) (En,Fr,De,Es,It) | |
| CSI - Crime Scene Investigation - Dark Motives (Europe) (En,Fr,De,Es,It) | |
| CSI - Crime Scene Investigation - Dark Motives (USA) (En,Fr,De,Es,It) | |
| CSI - Crime Scene Investigation - Deadly Intent - The Hidden Cases (Europe) (En,Fr,De,Es,It) | |
| CSI - Crime Scene Investigation - Deadly Intent - The Hidden Cases (USA) (En,Fr,Es) | |
| CSI - Crime Scene Investigation - Unsolved! (Europe) (En,Fr,De,Es,It) (NDSi Enhanced) | |
| Cuisine Party (France) | |
| Culdcept DS (Japan) | |
| Culture Generale pour les Nuls, La - 2e Edition (Europe) (En,Fr,De) | |
| Culture Generale pour les Nuls, La (France) | |
| Curling DS (USA) (En,Fr) | |
| Custom Battler Bomber Man (Japan) | |
| Custom Beat Battle - Draglade (Japan) | |
| Custom Beat Battle - Draglade 2 (Japan) | |
| Custom Mahjong (Japan) | |
| Custom Robo Arena (Europe) (En,Fr,De,Es,It) | |
| Custom Robo Arena (USA) | |