| Yajuu Deka - Tokyo Douji Tahatsu Terror o Chinatsu Seyo! (Japan) | |
| Yakitate!! Japan - Game Ichigou - Choujou Kessen!! Pantasic Grand Prix! (Japan) | |
| Yakuman DS (Japan) | |
| Yamaha Supercross (Europe) (En,Fr,De,Es,It) | |
| Yamaha Supercross (USA) | |
| Yamakawa Shuppansha Kanshuu - Shousetsu Nihonshi B - Sougou Training (Japan) | |
| Yamakawa Shuppansha Kanshuu - Shousetsu Sekaishi B - Sougou Training (Japan) | |
| Yamanote-sen Meimei 100 Shuunen Kinen - Densha de Go! - Tokubetsu Hen - Fukkatsu! Shouwa no Yamanote-sen (Japan) | |
| Yangsonui Darin (Korea) | |
| Yard Sale Hidden Treasures - Sunnyville (USA) (En,Fr,Es) | |
| Yatsuhaka Mura (Japan) | |
| Yatterman DS - Bikkuri Dokkiri Daisakusen da Koron (Japan) | |
| Yatterman DS 2 - Bikkuri Dokkiri Animal Daibouken (Japan) | |
| Yawaraka Atama Juku (Japan) | |
| Yeoksa Simulation - Samgukji DS (Korea) | |
| Yeoksa Simulation - Samgukji DS 2 (Korea) | |
| Yes! PreCure 5 (Japan) | |
| Yes! PreCure 5 Go Go! - Zenin Shuu-Go! Dream Festival (Japan) | |
| Yggdra Unison - Seiken Buyuuden (Japan) | |
| Yogi Bear - The Video Game (Europe) (En,Fr,De,Es,It) | |
| Yogi Bear (USA) (En,Fr,De,Es,It) | |
| Yokojiku de Manabu Sekai no Rekishi - Yoko Gaku DS (Japan) | |
| Yokoyama Mitsuteru Sangokushi - Dai-1-kan - Touen no Chikai (Japan) | |
| Yokoyama Mitsuteru Sangokushi - Dai-2-kan - Ryofu no Matsuro (Japan) | |
| Yokoyama Mitsuteru Sangokushi - Dai-3-kan - Sanko no Rei (Japan) | |
| Yokoyama Mitsuteru Sangokushi - Dai-4-kan - Sangoku Teiritsu (Japan) | |
| Yokoyama Mitsuteru Sangokushi - Dai-5-kan - Suishi no Hyou (Japan) | |
| Yokoyama Mitsuteru Sangokushi - Dai-6-kan - Koumei no Yuigon (Japan) | |
| Yomesou de Yomenai Kanji DS (Japan) | |
| Yoshi Island DS (Japan) | |
| Yoshi Touch & Go (Europe) (En,Fr,De,Es,It) | |
| Yoshi Touch & Go (USA) | |
| Yoshi's Island DS (Europe) (En,Fr,De,Es,It) | |
| Yoshi's Island DS (Korea) | |
| Yoshi's Island DS (USA) | |
| yoSumin. DS (Japan) | |
| You Don't Know Jack (USA) (NDSi Enhanced) | |
| Youda Farmer (Europe) (Fr,Nl) (NDSi Enhanced) | |
| Yozemi no Center Shoujun Series - Eigo Hen (Japan) | |
| Ys DS (Japan) | |
| Ys II DS (Japan) | |
| Ys Strategy (Europe) | |
| Ys Strategy (Japan) | |
| Yu Yu Hakusho DS - Ankoku Bujutsukai Hen (Japan) | |
| Yu-Gi-Oh! - Nightmare Troubadour (Europe) (En,Fr,De,Es,It) | |
| Yu-Gi-Oh! - Nightmare Troubadour (USA) | |
| Yu-Gi-Oh! - World Championship 2007 (Europe) (En,Ja,Fr,De,Es,It) | |
| Yu-Gi-Oh! - World Championship 2007 (USA) (En,Ja) | |
| Yu-Gi-Oh! - World Championship 2008 (Europe) (En,Ja,Fr,De,Es,It) | |
| Yu-Gi-Oh! - World Championship 2008 (Korea) (En,Ja,Ko) | |