| Zac to Ombra - Maboroshi no Yuuenchi (Japan) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS (Japan) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS (Japan) (Rev 1) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS (Japan) (Rev 2) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS (Japan) (Rev 4) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS (Japan) (Rev 5) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS 2 + Jouyou Kanji Jiten (Japan) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS 2 + Jouyou Kanji Jiten (Japan) (Rev 1) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kounin - Kanken DS 3 Deluxe (Japan) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Koushiki Soft - 200 Mannin no Kanken - Tokoton Kanji Nou (Japan) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Koushiki Soft - 200 Mannin no Kanken - Tokoton Kanji Nou (Japan) (Rev 1) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Koushiki Soft - 250 Mannin no Kanken - Shin Tokoton Kanji Nou 47,000 + Jouyou Kanji, Yoji Jukugo Jiten (Japan) | |
| Zaidan Houjin Nihon Kanji Nouryoku Kentei Kyoukai Kyouryoku - Kanken DS Training (Japan) (NDSi Enhanced) | |
| Zarah - Das Schloss des Gwoor (Europe) (En,Fr,De,Es,It) | |
| Zeldaui Jeonseol - Monghwanui Moraesigye (Korea) | |
| Zendoku (Europe) (En,Fr,De,Es,It) | |
| Zendoku (USA) (En,Fr,De,Es,It) | |
| Zenmai Zamurai (Japan) | |
| Zennou Series Vol. 01 - Akiyama Jin Kyouju Kanshuu - Zennou JinJin (Japan) | |
| Zennou Series Vol. 02 - Sakurai Susumu Sensei Kanshuu - India Shiki Keisan Zennou Drill (Japan) | |
| Zennou Series Vol. 03 - Akiyama Jin Kyouju Kanshuu - Zennou JinJin 2 (Japan) | |
| Zenses - Ocean (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Zenses - Ocean (USA) (En,Fr,Es) | |
| Zenses - Rainforest (Europe) (En,Fr,De,Es,It,Sv,No,Da) | |
| Zenses - Rainforest (USA) (En,Fr,Es) | |
| Zero kara Hajimeru - Otona no 5 Kakokugo Nyuumon - Ei, Futsu, Doku, I, Sei (Japan) | |
| Zero kara Kantan Chuugokugo DS (Japan) | |
| Zero kara Kantan Kankokugo DS (Japan) | |
| Zettai Karen Children DS - Dai-4 no Children (Japan) | |
| Zettai Onkan Otodamaster (Japan) | |
| Zettai Onkan Otodamaster (Japan) (Rev 1) | |
| Zettai Zetsumei Dangerous Jiisan DS - Dangerous Sensation (Japan) | |
| Zhu Zhu Pets (Europe) | |
| Zhu Zhu Pets (USA) | |
| Zhu Zhu Pets 2 - Featuring the Wild Bunch (USA) (En,Fr) (NDSi Enhanced) | |
| Zhu Zhu Pets featuring the Wild Bunch (Europe) (En,Fr,De,Es,It) (NDSi Enhanced) | |
| Zoey 101 - Field Trip Fiasco (USA) | |
| Zoids Battle Colosseum (Japan) | |
| Zoids Dash (Japan) | |
| Zoids Saga DS - Legend of Arcadia (Japan) | |
| Zombie Daisuki (Japan) | |
| Zombie Shiki - Eigo Ryoku Sosei Jutsu - English of the Dead (Japan) | |
| Zoo Hospital (Europe) | |
| Zoo Hospital (Europe) (En,Fr,De,Es,It) | |
| Zoo Hospital (USA) | |
| Zoo Keeper (Europe) (En,Fr,De,Es,It) | |
| Zoo Keeper (Japan) | |
| Zoo Keeper (USA) | |
| Zoo Quest - Puzzle Fun! (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da,Fi,Hu) | |
| Zoo Quest - Puzzle Fun! (USA) | |