| Electroplankton (USA) | |
| Eledees - The Adventures of Kai and Zero (Europe) (En,Fr,De,Es,It) | |
| Element Girls - Love, Fashion & Friends (Europe) (En,Fr,De,Es,It) | |
| Element Girls - Style Your Life! (Europe) (Fr,De) | |
| Element Girls (Germany) | |
| Element Hunters (Japan) | |
| Element Hunters (Korea) | |
| Elemental Monster - Itsu Hashira Gami no Nazo (Japan) | |
| Elements of Destruction (Europe) (En,Fr,De,Es) | |
| Elements of Destruction (USA) | |
| Elf Bowling 1 & 2 (USA) | |
| Elite Beat Agents (Europe) | |
| Elite Beat Agents (France) | |
| Elite Beat Agents (Germany) | |
| Elite Beat Agents (Italy) | |
| Elite Beat Agents (Spain) | |
| Elite Beat Agents (USA) | |
| Elite Forces - Unit 77 (Europe) (En,Fr,De,Es,It) | |
| Elite Forces - Unit 77 (USA) (En,Fr,De,Es,It) | |
| Ellen Whitaker's Horse Life (Europe) (En,Fr,De,Es,It,Nl) | |
| Elminage - Yami no Miko to Kamigami no Yubiwa - DS Remix (Japan) | |
| Elminage II - Sousei no Megami to Unmei no Daichi - DS Remix (Japan) (NDSi Enhanced) | |
| Elvenland (Europe) (En,Fr,De) | |
| Emblem of Gundam (Japan) | |
| Emergency (Europe) (En,Fr,Es,It,Nl) | |
| Emergency 2012 (Germany) | |
| Emergency DS (Germany) | |
| Emergency Room - Real Life Rescues (USA) | |
| Emily - My Animal Shelter (Europe) (En,Fr,It) | |
| Emily - My Dog Paradise (Europe) (En,Fr,It) | |
| Emily - My Personal Diary (Europe) (En,Fr,De,Es,It,Nl) | |
| Emma at the Farm (Europe) (En,De,Sv,No,Da,Fi) | |
| Emma at the Farm (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Emma at the Farm (USA) (En,Fr,Es) | |
| Emma in the Mountains (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Emma in the Mountains (USA) (En,Fr,Es) | |
| Enchanted (Europe) (En,Fr,De,Es,It,Nl) | |
| Enchanted (USA) (En,Fr,De,Es,It,Nl) | |
| Enchanted Folk and the School of Wizardry (Europe) (En,Fr,De,Es,It) | |
| Ener-G - Dance Squad (USA) (En,Fr,Es) | |
| Ener-G - Gym Rockets (USA) (En,Fr,Es) | |
| Ener-G - Horse Riders (USA) (En,Fr,Es) | |
| Englisch Buddy (Europe) (En,Fr,De,Es,It,Nl) | |
| Englisch Buddy (Europe) (En,Fr,De) | |
| Englisch Macht Spass - Eine Reise nach London! (Germany) | |
| English Training - Have Fun Improving Your Skills (Europe) (Fr,De,Es,It,Nl) | |
| Enpitsu de Oku no Hosomichi DS (Japan) | |
| Entraineur Cerebral, L' - Kids (France) | |
| Entraineur Cerebral, L' - Logique (France) | |
| Entraineur Cerebral, L' - Perception (France) | |