| Shugo Chara! - Nori Nori! CharanaRhythm (Japan) | |
| Shunkan Puzz Loop (Japan) | |
| Shuwa no Mori (Japan) | |
| Sid Meier's Civilization Revolution (Europe) (En,Fr,De,Es,It) | |
| Sid Meier's Civilization Revolution (Japan) | |
| Sid Meier's Civilization Revolution (USA) (En,Fr,De,Es,It) | |
| Sideswiped (USA) | |
| Sight Training - Enjoy Exercising and Relaxing Your Eyes (Europe) (En,Fr,De,Es,It) | |
| Sightseeing Puzzle - Echter Puzzlespass fuer Unterwegs (Europe) (En,Fr,De,Es,It) | |
| Sigma Harmonics (Japan) | |
| Signal (Japan) | |
| Silke - Pixelines Lillesoester - Hoensefoedder og Guleroedder (Denmark) | |
| Silke - Pixelines Lillesoester - Syng, Leg og Laer (Denmark) | |
| Sillybandz DS (USA) (En,Fr,Es) | |
| SimAnimals - Africa (Europe) (En,Ja,Fr,De,Nl,Pt) | |
| SimAnimals - Africa (Japan) (En,Ja) | |
| SimAnimals - Africa (USA) (En,Ja,Fr,De,Nl,Pt) | |
| SimAnimals (Europe) (En,Fr,De,Es,It,Nl,Pt,Sv,No,Da) | |
| SimAnimals (Japan) (En,Ja) | |
| SimAnimals (Korea) (En,Ko) | |
| SimAnimals (USA) (En,Fr,De,Es,It,Nl,Pt,Sv,No,Da) | |
| SimCity - Creator (Europe) (En,Fr,De,Es,It,Nl) | |
| SimCity - Creator (Korea) | |
| SimCity - Creator (USA) (En,Fr,Es) | |
| SimCity DS - The Ultimate City Simulator (Japan) | |
| SimCity DS - The Ultimate City Simulator (Japan) (Rev 1) | |
| SimCity DS (Europe) (En,Fr,De,Es,It,Nl) | |
| SimCity DS (Korea) | |
| SimCity DS (USA) (En,Fr,De,Es,It,Nl) | |
| SimCity DS 2 - Kodai kara Mirai e Tsuzuku Machi (Japan) | |
| Simple DS Series Vol. 1 - The Mahjong (Japan) | |
| Simple DS Series Vol. 10 - The Dokodemo Kanji Quiz (Japan) | |
| Simple DS Series Vol. 11 - Mou Ichido Kayoeru - The Otona no Shougakkou (Japan) | |
| Simple DS Series Vol. 12 - The Party Unou Quiz (Japan) | |
| Simple DS Series Vol. 13 - Ijoukishou o Tsuppashire - The Arashi no Drift Rally (Japan) | |
| Simple DS Series Vol. 14 - The Jidousha Kyoushuujo DS (Japan) | |
| Simple DS Series Vol. 15 - The Kanshikikan 2 - Aratanaru Yattsu no Jiken o Touch Seyo (Japan) | |
| Simple DS Series Vol. 15 - The Kanshikikan 2 - Aratanaru Yattsu no Jiken o Touch Seyo (Japan) (Rev 1) | |
| Simple DS Series Vol. 16 - The Sagasou Fushigi na Konchuu no Mori (Japan) | |
| Simple DS Series Vol. 17 - The Nezumi no Action Game - Mouse Town Roddy to Rita no Daibouken (Japan) | |
| Simple DS Series Vol. 18 - The Soukou Kihei Gun Ground (Japan) | |
| Simple DS Series Vol. 19 - Yareba Dekiru! - The Micro Step Gijutsu de Oboeru Eitango (Japan) | |
| Simple DS Series Vol. 2 - The Billiard (Japan) (Rev 1) | |
| Simple DS Series Vol. 20 - The Senkan (Japan) | |
| Simple DS Series Vol. 21 - The Hohei - Butai de Shutsugeki! Senjou no Inu-tachi (Japan) | |
| Simple DS Series Vol. 22 - Age Age - The Zero-Yon Midnight (Japan) | |
| Simple DS Series Vol. 23 - The Puzzle Quest - Agaria no Kishi (Japan) | |
| Simple DS Series Vol. 23 - The Puzzle Quest - Agaria no Kishi (Japan) (Rev 1) | |
| Simple DS Series Vol. 24 - The Sensha (Japan) | |
| Simple DS Series Vol. 25 - The Koushounin (Japan) | |