| Sims 3, The (Europe) (En,Fr,De,Es,It,Nl) (NDSi Enhanced) | |
| Six Flags Fun Park (USA) (En,Fr) | |
| Skate It (Europe) (En,Fr,De,Es,It,Nl) | |
| Skate It (USA) (En,Fr,De,Es,It,Nl) | |
| Slide Adventure - Mag Kid (Japan) | |
| Slime Morimori Dragon Quest 2 - Daisensha to Shippo Dan (Japan) | |
| Slingo Quest (USA) | |
| Sloane to MacHale no Nazo no Story (Japan) | |
| Sloane to MacHale no Nazo no Story 2 (Japan) | |
| Smart Boy's Gameroom (USA) | |
| Smart Boy's Gameroom 2 (USA) | |
| Smart Boy's Toys Club (USA) | |
| Smart Boy's Winter Wonderland (USA) | |
| Smart Girl's Magical Book Club (USA) | |
| Smart Girl's Party Game (USA) | |
| Smart Girl's Playhouse (USA) | |
| Smart Girl's Playhouse 2 (USA) | |
| Smart Girl's Winter Wonderland (USA) | |
| Smart Kid's Gameclub (USA) | |
| Smart Kid's Mega Game Mix (USA) | |
| Smart Kid's Party Fun Pak (USA) | |
| SmileyWorld - Island Challenge (Europe) (En,Fr,De,Es,It) | |
| SmileyWorld - Island Challenge (USA) (En,Fr,Es) | |
| Smurfs 2, The (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Smurfs 2, The (USA) (En,Fr,Es) | |
| Smurfs, The (Europe) (En,Fr) | |
| Smurfs, The (USA) (En,Fr) | |
| SNES Mario | |
| SNK vs. Capcom - Card Fighters DS (Europe) (En,Fr,De,Es,It) | |
| SNK vs. Capcom - Card Fighters DS (Japan) | |
| SNK vs. Capcom - Card Fighters DS (USA) | |
| SNK vs. Capcom - Card Fighters DS (USA) (Rev 1) | |
| Snood 2 - On Vacation (Europe) (En,Fr,De,Es,It) | |
| Snood 2 - On Vacation (USA) | |
| Snoopy DS - Snoopy to Nakama-tachi ni Ai ni Ikou! (Japan) | |
| Snoopy no Aiken DS - Shitte Okitai Inu no Koto, Inu no Nouryoku, Anata no Shitsuke (Japan) | |
| Snoopy to Issho ni DS Eigo Lesson (Japan) | |
| Snowboard Kids Party (Japan) | |
| So Blonde - Back to the Island (Europe) (En,Fr,De,Es,It) | |
| Sofie - Josefines Lillesoester - Syng, Lek og Laer (Norway) | |
| Sokoban DS (Europe) (En,Fr,De,Es,It) | |
| Solatorobo - Sorekara Coda e (Japan) (NDSi Enhanced) | |
| Solitaire (Europe) (En,Fr,De,Es,It) | |
| Solitaire DS (Europe) (En,Fr,De,Es,It) | |
| Solitaire Mahjong - Ancient China Adventure (Europe) (En,Fr,De,Es,It) | |
| Solitaire Overload (USA) | |
| Solitaire Overload Plus (USA) (En,Fr,Es) | |
| Soma Bringer (Japan) | |
| Sommelier DS (Japan) | |
| Sonic & Sega All-Stars Racing (Europe) (En,Fr,De,Es,It) | |