| Curling DS (USA) (En,Fr) | |
| Custom Battler Bomber Man (Japan) | |
| Custom Beat Battle - Draglade (Japan) | |
| Custom Beat Battle - Draglade 2 (Japan) | |
| Custom Mahjong (Japan) | |
| Custom Robo Arena (Europe) (En,Fr,De,Es,It) | |
| Custom Robo Arena (USA) | |
| D.Gray-Man - Innocence no Shito-tachi (Japan) | |
| D&CO - Ta Maison de Reve en 7 Jours (Europe) (Fr,It) | |
| Daigassou! Band-Brothers (Japan) | |
| Daigassou! Band-Brothers DX (Japan) | |
| Daigassou! Band-Brothers DX (Japan) (Rev 1) | |
| Daikoukai Jidai IV - Rota Nova (Japan) | |
| Daisenryaku DS - Great Strategy (Japan) | |
| Daito Giken Koushiki Pachi-Slot Simulator Hihouden - Ossu! Banchou - Yoshimune DS (Japan) | |
| Dance Floor (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Dance! - It's Your Stage (Europe) (En,De) (NDSi Enhanced) | |
| Dancing on Ice (Europe) | |
| Dancing with the Stars - We Dance! (USA) | |
| Daniel X - The Ultimate Power (USA) (En,Fr,De,Es,It) (NDSi Enhanced) | |
| Danny Phantom - Urban Jungle (Europe) (En,Fr,De,Es) | |
| Danny Phantom - Urban Jungle (USA) | |
| Danshaku (Japan) | |
| Daredemo Asobi Taizen (Japan) | |
| Daredemo Kantan! - Jo Chihun no Tsumego (Japan) | |
| Daredemo Kantan! - Watanabe Akira no Tsumeshougi (Japan) | |
| Daring Game for Girls, The (USA) | |
| Dark Spire, The (USA) | |
| Das Weiss Doch Jedes Kind! (Germany) | |
| Date ni Gametsui Wake ja Nee! - Dungeon Maker Girls Type (Japan) | |
| Datenshi no Amai Yuuwaku x Kaikan Phrase (Japan) | |
| Dawn of Discovery (USA) (En,Fr,De,Es,It) | |
| Dawn of Heroes (USA) | |
| Days of Memories (Japan) | |
| Days of Memories 2 (Japan) | |
| Days of Memories 3 (Japan) | |
| de Blob 2 (Europe) (En,Fr,De,Es,It,Nl) (NDSi Enhanced) | |
| de Blob 2 (USA) | |
| Dead'n'Furious (Europe) (En,Fr,De,Es,It) | |
| Deal or No Deal - Der Banker Schlaegt Zurueck (Germany) | |
| Deal or No Deal - Special Edition (USA) (En,Fr,Es) | |
| Deal or No Deal - The Banker Is Back! (Europe) | |
| Deal or No Deal - The Official Nintendo DS Game (Europe) | |
| Deal or No Deal (Australia) | |
| Deal or No Deal (Germany) | |
| Deal or No Deal (Netherlands) | |
| Deal or No Deal (USA) | |
| Dear Girl - Stories - Hibiki - Hibiki Tokkun Daisakusen! (Japan) | |
| Death Jr. and the Science Fair of Doom (Europe) (En,Fr,De,Es,It) | |
| Death Jr. and the Science Fair of Doom (USA) | |