| Saikyou Toudai Shougi DS (Japan) | |
| Sailor Moon - The Shining Moon (Italy) [T-En v1.0] | |
| Saitou Takashi no DS de Yomu - Sanshoku Ballpen Meisaku Juku (Japan) | |
| Saiyuuki Kinkaku Ginkaku no Inbou (Japan) | |
| Saka Tsuku DS - Touch and Direct (Japan) | |
| Saka Tsuku DS - World Challenge 2010 (Japan) | |
| Sakana to Asobou! - Aquazone DS - Kaisuigyo (Japan) | |
| Sakasete! Chibi-Robo! (Japan) | |
| Sakashou DS (Japan) | |
| Sakura Note - Ima ni Tsunagaru Mirai (Japan) | |
| Sakusaku Jinkou Kokyuu Care Training DS (Japan) | |
| Sally's Salon (USA) | |
| Sam Power - Firefighter (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Sam Power - Footballer (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Sam Power - Handyman (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Sam Power - Policeman (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da) | |
| Samantha Oups! - Le Jeu (France) | |
| Samantha Swift and the Hidden Roses of Athena (Europe) (En,Nl) | |
| Samantha Swift and the Hidden Roses of Athena (Germany) | |
| Samantha Swift and the Hidden Roses of Athena (USA) | |
| San-X Character Channel - All-Star Daishuugou! (Japan) | |
| San-X Character Sagashi Land (Japan) | |
| San-X Land - Theme Park de Asobou! (Japan) | |
| Sands of Destruction (USA) | |
| Sangokushi Taisen DS (Japan) | |
| Sangokushi Taisen Ten (Japan) | |
| Sankei Sports Kanshuu - Keiba Ryoku Nintei Shiken - Baken DS (Japan) | |
| Sankei Sports Kanshuu - Wi-Fi Baken Yosou Ryoku Training - Umania 2007 Nendo Ban (Japan) | |
| Sansuu Olympic Iinkai Kouan - Suuji de Kitaeru Nouryoku Training - Algo & Trinca (Japan) | |
| Sansuu Puzzle de Migaku - Gakken Otona no Shikou Sense (Japan) | |
| Sansuu Puzzle Game - Equal Card DS (Japan) | |
| Santa Claus is Comin' to Town (USA) | |
| Sarah - Die Hueterin des Einhorns (Europe) (Fr,De) | |
| Sarah - Keeper of the Unicorn (USA) (En,Es) | |
| Sarainneun Yeongeoro Ganghaejineun Siljeon! - DS Yeongeo Sammaegyeong (Korea) | |
| Saru Saru DS (Japan) | |
| Satisfashion - Rock the Runway (USA) | |
| Sawaru Made in Wario (Japan) | |
| Sawaru Made in Wario (Japan) (Rev 2) | |
| SBI Group Kanshuu - Hajimeyou! Shisan Unyou DS (Japan) | |
| SBK - Snowboard Kids (Europe) (En,Fr,De) | |
| SBK - Snowboard Kids (USA) | |
| Scene It Twilight (Europe) (En,Fr,De,Es,It) | |
| Scene It Twilight (USA) (En,Fr,Es) | |
| Schaakmat! (Netherlands) (En,Nl) | |
| Schach (Germany) (En,De) | |
| Schach & Matt (Germany) | |
| Schach Attacke (Germany) | |
| Schatz der Delfine, Der (Europe) (En,Fr,De,Es,It) | |
| Science Papa (Europe) (En,Fr,De,Es,It) | |