| International Athletics (Europe) (En,Fr,De,Es,It) | |
| Intervilles - Fais Gagner Ta Ville! - Le Jeu Officiel (France) | |
| Inu Gaisha (Japan) | |
| Inugamike no Ichizoku (Japan) | |
| InuYasha - Secret of the Divine Jewel (USA) | |
| Ippan Zaidan Houjin Nihon Kanji Shuujukudo Kentei Kikou Kounin - Kanjukuken DS (Japan) | |
| Iron Chef America - Supreme Cuisine (USA) | |
| Iron Feather (Japan) | |
| Iron Man (Europe) (En,Fr,De,Es,It) | |
| Iron Man (USA) (En,Fr,Es) | |
| Iron Man 2 - The Video Game (Europe) (En,Fr,De,Es,It) | |
| Iron Man 2 (USA) (En,Fr,Es) | |
| Iron Master - The Legendary Blacksmith (Japan) | |
| Iron Master - Wanggugui Yusangwa Segaeui Yeolsoe (Korea) | |
| Irozuki Tingle no Koi no Balloon Trip (Japan) | |
| Isanghan Naraui Princess (Korea) | |
| Ishin no Arashi - Shippuu Ryouma Den (Japan) | |
| Isola dei Famosi, L' (Italy) | |
| It's Tehodoki! Hannya Shingyou Nyuumon (Japan) | |
| Item Getter - Bokura no Kagaku to Mahou no Kankei (Japan) | |
| Itouke no Urawaza DS (Japan) | |
| Itsudemo Dokodemo - Onita Atsushi no Seiji Quiz DS (Japan) | |
| Itsudemo Dokodemo Dekiru Igo - AI Igo DS (Japan) | |
| Itsudemo Dokodemo Dekiru Shougi - AI Shougi DS (Japan) | |
| Itsumo no Shokuzai de Dekichau Suteki na Sweets to Gochisou. (Japan) | |
| Itsuwari no Rondo (Japan) | |
| Ivy the Kiwi - Tsuta ga Michibiku Monogatari. (Japan) | |
| Ivy the Kiwi (Europe) (En,Fr,De,Es,It) | |
| Ivy the Kiwi (USA) (En,Fr,Es) | |
| Izuna - Legend of the Unemployed Ninja (USA) | |
| Izuna - The Legend of the Ninja (Europe) (En,Fr,It) | |
| Izuna 2 - The Unemployed Ninja Returns (USA) | |
| J'Apprends l'Anglais CP-CM1 (Europe) (Fr,It) | |
| J4G - A Girl's World (Europe) (En,De) | |
| Jackass - The Game DS (Europe) (En,Fr,De,Es,It) | |
| Jackass - The Game DS (USA) | |
| Jacqueline Wilson's Tracy Beaker - The Game (Europe) | |
| Jagged Alliance (USA) | |
| Jaka Jaka Music! M09 (Japan) | |
| Jake Hunter - Detective Chronicles (USA) | |
| Jake Hunter Detective Story - Memories of the Past (USA) | |
| Jake Power - Firefighter (Australia) (En,Fr,Es) | |
| Jake Power - Fireman (USA) (En,Fr,Es) | |
| Jake Power - Handyman (Australia) (En,Fr,Es) | |
| Jake Power - Handyman (USA) (En,Fr,Es) | |
| Jake Power - Policeman (Australia) (En,Fr,Es) | |
| Jake Power - Policeman (USA) (En,Fr,Es) | |
| Jam Sessions - Sing & Play Guitar (Europe) (En,Fr,De,Es,It,Nl) | |
| Jam Sessions - Sing and Play Guitar (USA) (En,Fr,De,Es,It,Nl) | |
| Jam Sessions 2 (USA) (En,Fr,Es) (NDSi Enhanced) | |