| Rockman ZX (Japan) | |
| Rollercoaster Park (Europe) (En,Fr,Nl) | |
| Rollin' Rascals (USA) | |
| Rondo of Swords (USA) | |
| Roogoo Attack! (USA) (En,Fr,De,Es,It) | |
| Rooms - Fushigi na Ugoku Heya (Japan) | |
| Rooms - The Main Building (Europe) (En,Fr,De,Es,It) | |
| Rooms - The Main Building (USA) (En,Fr,Es) | |
| Rosalina and Luma | |
| Rosario to Vampire - Tanabata no Miss Youkai Gakuen (Japan) | |
| RPG Tkool DS (Japan) (NDSi Enhanced) | |
| Rub Rabbits!, The (Europe) (En,Ja,Fr,De,Es,It) | |
| Rub Rabbits!, The (USA) (En,Ja,Fr,De,Es,It) | |
| Rubik's Puzzle World (Europe) (En,Fr,De,Es,It) | |
| Rubik's World (USA) | |
| Rudolph - The Red-Nosed Reindeer (USA) | |
| Runaway - A Twist of Fate (Europe) (En,Fr,De,Es,It) | |
| Runaway - The Dream of the Turtle (Europe) (En,Fr,De,Es,It) (Rev 1) | |
| Runaway - The Dream of the Turtle (Europe) (En,Fr,De) | |
| Rune Factory - A Fantasy Harvest Moon (Europe) (En,Fr,De,Es,It) | |
| Rune Factory - A Fantasy Harvest Moon (USA) | |
| Rune Factory - Shin Bokujou Monogatari (Japan) | |
| Rune Factory - Sinmokjjangiyagi (Korea) | |
| Rune Factory 2 - A Fantasy Harvest Moon (Europe) (En,De) | |
| Rune Factory 2 - A Fantasy Harvest Moon (USA) | |
| Rune Factory 2 (Japan) | |
| Rune Factory 2 (Japan) (Rev 1) | |
| Rune Factory 3 - A Fantasy Harvest Moon (USA) | |
| Rune Factory 3 (Japan) | |
| Rupupu Cube - Lup Salad DS (Japan) | |
| Russel Grant's Astrology (Europe) (En,Fr,De,Es,It) | |
| Ryoukiki Exercise - Riron no Migite to Kansei no Hidarite (Japan) | |
| Ryuusei no Rockman - Dragon (Japan) | |
| Ryuusei no Rockman - Leo (Japan) | |
| Ryuusei no Rockman - Pegasus (Japan) | |
| Ryuusei no Rockman 2 - Berserk x Dinosaur (Japan) | |
| Ryuusei no Rockman 2 - Berserk x Shinobi (Japan) | |
| Ryuusei no Rockman 3 - Black Ace (Japan) (Rev 1) | |
| Ryuusei no Rockman 3 - Red Joker (Japan) (Rev 1) | |
| Saeki Chizu Shiki Yumemihada - Dream Skincare (Japan) | |
| Safari Adventures - Africa (Europe) (En,Fr,De,Es,It,Nl) | |
| Safari Adventures - Africa (USA) | |
| Safecracker - The Ultimate Puzzle Adventure (Europe) (En,Fr,De,Es,It) | |
| Safecracker - The Ultimate Puzzle Challenge! (USA) (En,Fr,Es) | |
| SaGa 2 - Hihou Densetsu - Goddess of Destiny (Japan) | |
| SaGa 3 - Jikuu no Hasha - Shadow or Light (Japan) | |
| Saga no Gabai Baachan DS (Japan) | |
| Saibanin Suiri Game - Yuuzai x Muzai (Japan) | |
| Saihai no Yukue (Japan) | |
| Saikin Koi Shiteru (Japan) | |