| DS Kageyama Method Dennou Hanpuku - Masu x Masu Hyaku Masu Keisan (Japan) | |
| DS Kageyama Method Dennou Hanpuku - Masu x Masu Pre-Hyaku Masu Keisan - Hyaku Masu no Mae ni Kore Da yo! (Japan) | |
| DS Kageyama Method Dennou Hanpuku - Tadashii Kanji Kakitori-kun - Kondo wa Kanken Taisaku Da yo! (Japan) | |
| DS Kageyama Method Dennou Hanpuku - Tadashii Kanji Kakitori-kun (Japan) | |
| DS Motte Tabi ni Deyo - Kyoto (Japan) | |
| DS Nishimura Kyotaro Suspense 2 Shin Tantei Series - Kanazawa, Hakodate, Gokkan no Kyoukoku - Fukushuu no Kage (Japan) | |
| DS Nishimura Kyotaro Suspense Shin Tantei Series - Kyoto, Atami, Zekkai no Kotou - Satsui no Wana (Japan) | |
| DS Puzzler - Nanpure Fan & Oekaki Logic - Wi-Fi Taiou (Japan) | |
| DS Puzzler - Nanpure Fan & Oekaki Logic (Japan) | |
| DS Rakubiki Jiten (Japan) | |
| DS Teku Teku Nikki - Walking & Diet Diary (Japan) | |
| DS Uranai Seikatsu (Japan) | |
| DS Vitamin - Widaehan Bapsang - Malhaneun! Geongangyori Giljabi (Korea) | |
| DS Yamamura Misa Suspense - Maiko Kogiku, Kisha Catherine, Sougiya Ishihara Akiko - Koto ni Mau Hana Sanrin - Kyoto Satsujin Jiken File (Japan) | |
| DS Yukemuri Suspense Series - Free Writer Tachibana Maki - Touyako, Nanatsu no Yu, Okuyu no Sato - Shuzai Techou (Japan) | |
| DS-PICO Series - Sanrio no Party e Ikou! - Oryouri, Oshare, Okaimono (Japan) | |
| DTM Race Driver 3 - Create & Race (Germany) (En,Fr,De,Es,It) | |
| Ducati Moto (Europe) (En,Fr,De,Es,It) | |
| Ducati Moto (USA) | |
| Duel Love - Koisuru Otome wa Shouri no Megami (Japan) | |
| Duke Nukem - Critical Mass (Europe) (En,Fr,De,Es,It) | |
| Dun-Dam - Dungeons & Dam (Japan) | |
| Dungeon Explorer - Jashin no Ryouiki (Japan) | |
| Dungeon Explorer - Warriors of Ancient Arts (USA) | |
| Dungeon Explorer (Europe) (En,Fr,De,Es,It) | |
| Dungeon Maker - Mahou no Shovel to Chiisana Yuusha (Japan) | |
| Dungeon Maker (Europe) (En,Fr,De,Es,It) | |
| Dungeon of Windaria (Japan) | |
| Dungeon Raiders (Europe) (En,Fr,De,Es,It) | |
| Dynasty Warriors DS - Fighter's Battle (Europe) (En,Fr,De,Es,It) | |
| Dynasty Warriors DS - Fighter's Battle (USA) | |
| E=M6 Defi Cerebral (France) | |
| EA Playground (Europe) (En,Fr,De,Es,It) | |
| EA Playground (Korea) | |
| EA Playground (USA) (En,Fr,De,Es,It) | |
| Easy Learning - Discover Our World (Europe) (En,Fr,De,Es,It) | |
| Easy Piano - Learn, Play & Compose (Europe) (En,Fr,De,Es,It) | |
| Easy Piano (USA) (En,Fr,Es) | |
| Eco-Creatures - Save the Forest (USA) | |
| Ecolis - Aoi Umi to Ugoku Shima (Japan) | |
| Ecolis - Save the Forest (Europe) (En,Fr,De,Es,It) | |
| Ecolis (Japan) | |
| Ed, Edd n Eddy - Scam of the Century (Europe) (En,Fr,De,Es,It) | |
| Ed, Edd n Eddy - Scam of the Century (USA) | |
| Ed's Farm (Europe) (En,Fr,De,Es,It) | |
| Edamoto Naomi no Shiawase Kitchen - Kakushi Aji wa Anata ga Kimete ne (Japan) | |
| Edo Bunka Rekishi Kentei DS (Japan) | |
| Edogawa Ranpo no Kaijin Nijuu Mensou DS (Japan) | |
| Egg Monster Hero (Japan) | |
| Egokoro Kyoushitsu DS (Japan) (NDSi Enhanced) | |