| Ellen Whitaker's Horse Life (Europe) (En,Fr,De,Es,It,Nl) | |
| Elminage - Yami no Miko to Kamigami no Yubiwa - DS Remix (Japan) | |
| Elminage II - Sousei no Megami to Unmei no Daichi - DS Remix (Japan) (NDSi Enhanced) | |
| Elvenland (Europe) (En,Fr,De) | |
| Emblem of Gundam (Japan) | |
| Emergency (Europe) (En,Fr,Es,It,Nl) | |
| Emergency 2012 (Germany) | |
| Emergency DS (Germany) | |
| Emergency Room - Real Life Rescues (USA) | |
| Emily - My Animal Shelter (Europe) (En,Fr,It) | |
| Emily - My Dog Paradise (Europe) (En,Fr,It) | |
| Emily - My Personal Diary (Europe) (En,Fr,De,Es,It,Nl) | |
| Emma at the Farm (Europe) (En,De,Sv,No,Da,Fi) | |
| Emma at the Farm (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Emma at the Farm (USA) (En,Fr,Es) | |
| Emma in the Mountains (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Emma in the Mountains (USA) (En,Fr,Es) | |
| Enchanted (Europe) (En,Fr,De,Es,It,Nl) | |
| Enchanted (USA) (En,Fr,De,Es,It,Nl) | |
| Enchanted Folk and the School of Wizardry (Europe) (En,Fr,De,Es,It) | |
| Ener-G - Dance Squad (USA) (En,Fr,Es) | |
| Ener-G - Gym Rockets (USA) (En,Fr,Es) | |
| Ener-G - Horse Riders (USA) (En,Fr,Es) | |
| Englisch Buddy (Europe) (En,Fr,De,Es,It,Nl) | |
| Englisch Buddy (Europe) (En,Fr,De) | |
| Englisch Macht Spass - Eine Reise nach London! (Germany) | |
| English Training - Have Fun Improving Your Skills (Europe) (Fr,De,Es,It,Nl) | |
| Enpitsu de Oku no Hosomichi DS (Japan) | |
| Entraineur Cerebral, L' - Kids (France) | |
| Entraineur Cerebral, L' - Logique (France) | |
| Entraineur Cerebral, L' - Perception (France) | |
| EQ Trainer DS - Dekiru Otona no Communication Jutsu (Japan) | |
| Equestrian Training (Europe) | |
| Equitation - Galops 1 a 4 (France) | |
| Equitation - Galops 1 a 7 (France) | |
| Era Glaciale 3, L' - L'Alba dei Dinosauri (Italy) | |
| Eragon (Europe) (En,Fr,De,Es,It) | |
| Eragon (USA) | |
| Ermii Kart DS Legacy Edition | |
| Escape the Museum (Europe) (En,Fr,It) | |
| Escape the Museum (Europe) (En,Fr,Nl) | |
| Escape the Museum (Germany) | |
| Escape the Museum (USA) (En,Fr,De,Es) | |
| ESSE Shikkari Kakeibo DS (Japan) (Rev 1) | |
| Essential Sudoku DS (Europe) | |
| Estpolis - The Lands Cursed by the Gods (Japan) | |
| Etrian Odyssey (Europe) (En,Fr,De,Es,It) | |
| Etrian Odyssey (USA) | |
| Etrian Odyssey II - Heroes of Lagaard (USA) | |
| Etrian Odyssey III - The Drowned City (USA) | |