| Shinreigari - Ghost Hound DS (Japan) | |
| Shinri Kenkyuuka Yuki Yu Kanshuu - Mainichi Kokorobics - DS Therapy (Japan) | |
| Shinseiki Evangelion - Ayanami Ikusei Keikaku DS with Asuka Hokan Keikaku (Japan) | |
| Shion no Ou - The Flowers of Hard Blood (Japan) | |
| Shiseido Beauty Solution Kaihatsu Center Kanshuu - Project Beauty (Japan) | |
| Shoho kara Hajimeru - Otona no Eitango Renshuu (Japan) | |
| Shokugyou Taiken Adventure - 13-sai no Hello Work DS (Japan) | |
| Shorts (USA) (En,Fr) | |
| Shougi World Champion - Gekisashi DS (Japan) | |
| Shounen Kininden Tsumuji (Japan) | |
| Shounen Sunday & Shounen Magazine - White Comic (Japan) | |
| Showtime Championship Boxing (Europe) (En,Fr,De,Es,It) | |
| Showtime Championship Boxing (USA) | |
| Shrek - E Vissero Felici e Contenti (Italy) (NDSi Enhanced) | |
| Shrek - Forever After (Europe) (De,Es) (NDSi Enhanced) | |
| Shrek - Forever After (Europe) (En,Fr) (NDSi Enhanced) | |
| Shrek - Forever After (USA) (En,Fr) (NDSi Enhanced) | |
| Shrek - Oger und Dresel (Germany) | |
| Shrek - Ogres & Dronkeys (Europe) | |
| Shrek - Ogres & Dronkeys (Netherlands) | |
| Shrek - Ogres & Dronkeys (USA) | |
| Shrek - Ogres et Dranons (France) | |
| Shrek - Ogritos y Drasnos (Spain) | |
| Shrek - Orchetti e Ciuchini (Italy) | |
| Shrek - Smash n' Crash Racing (Europe) (En,Fr,De,Es,It) | |
| Shrek - Smash n' Crash Racing (USA) | |
| Shrek - Super Slam (Europe) (En,Fr,De,Es,It,Nl) | |
| Shrek - Super Slam (USA) | |
| Shrek de Derde (Netherlands) | |
| Shrek der Dritte (Germany) | |
| Shrek le Troisieme (France) | |
| Shrek Tercero (Spain) | |
| Shrek Terzo (Italy) | |
| Shrek the Third (Europe) | |
| Shrek the Third (USA) | |
| Shrek's Carnival Craze - Party Games (Europe) (En,Fr,De,Es,It,Nl) | |
| Shrek's Carnival Craze - Party Games (USA) (En,Fr) | |
| Shugo Chara! - 3-tsu no Tamago to Koisuru Joker (Japan) | |
| Shugo Chara! - Amu no Nijiiro Chara Change (Japan) | |
| Shugo Chara! - Nori Nori! CharanaRhythm (Japan) | |
| Shunkan Puzz Loop (Japan) | |
| Shuwa no Mori (Japan) | |
| Sid Meier's Civilization Revolution (Europe) (En,Fr,De,Es,It) | |
| Sid Meier's Civilization Revolution (Japan) | |
| Sid Meier's Civilization Revolution (USA) (En,Fr,De,Es,It) | |
| Sideswiped (USA) | |
| Sight Training - Enjoy Exercising and Relaxing Your Eyes (Europe) (En,Fr,De,Es,It) | |
| Sightseeing Puzzle - Echter Puzzlespass fuer Unterwegs (Europe) (En,Fr,De,Es,It) | |
| Sigma Harmonics (Japan) | |
| Signal (Japan) | |