| Death Note - Kira Game (English translation) | |
| Death Note - Kira Game (Japan) | |
| Death Note - L o Tsugu Mono (Japan) | |
| Deca Sporta - DS de Sports '10' Shumoku! (Japan) | |
| Deca Sports DS (USA) (En,Fr,Es) | |
| Deco Tendances (France) | |
| Deep Aquarium - Kiseki no Shinkai (Japan) | |
| Deep Labyrinth (Europe) | |
| Deep Labyrinth (Japan) | |
| Deep Labyrinth (USA) | |
| Deep Sea Aquarium by DS (Europe) (En,Fr,It) | |
| Defendin' DePenguin (USA) (En,Es) | |
| Deine Reitschule (Europe) (Fr,De) | |
| Dekiru Otoko no Mote Life - Hiru no Mote Kouza Hen (Japan) | |
| Dekiru Otoko no Mote Life - Yoru no Mote Jissen Hen (Japan) | |
| Dekita yo! Mama. - Mitsugo no Kuma-san - Onnanoko (Japan) | |
| Dekita yo! Mama. - Mitsugo no Kuma-san - Otokonoko (Japan) | |
| Dekita yo! Mama. - Wannyan Club - Onnanoko (Japan) | |
| Dekita yo! Mama. - Wannyan Club - Otokonoko (Japan) | |
| Deltora Quest - Nanatsu no Houseki (Japan) | |
| Dementium - The Ward (Europe) (En,Fr,De,Es,It) | |
| Dementium - The Ward (USA) | |
| Dementium II (Europe) (En,Fr,De,Es,It) | |
| Dementium II (USA) (En,Fr,De,Es,It) | |
| Dengeki Gakuen RPG - Cross of Venus (Japan) | |
| Dengeki Gakuen RPG - Cross of Venus Special (Japan) | |
| Denjirou Sensei no Fushigi na Jikkenshitsu (Japan) | |
| Denksport Varia (Netherlands) | |
| Densetsu no Stafy - Taiketsu! Dile Kaizoku Dan (Japan) | |
| Densetsu no Stafy 4 (Japan) | |
| Derby Stallion DS (Japan) | |
| Desktop Tower Defense (USA) | |
| Despicable Me - Minion Mayhem (Europe) (En,Fr,De,Es,It,Sv,No,Da,Fi) | |
| Despicable Me - The Game - Minion Mayhem (USA) (En,Fr,De,Es,It) | |
| Destiny Links (Japan) | |
| Deutgo Sseugo Chinhaejineun - DS Yeongeo Sammaegyeong (Korea) | |
| Deutsch 1.-4. Klasse - Fit fuers Gymnasium (Germany) | |
| Deviens Miss France (France) | |
| Devil Survivor 2 (Japan) | |
| Devilish - Ball Bounder (Japan) | |
| Devilish (Europe) | |
| Di-Gata Defenders (Europe) (En,Fr,De,Es,It) | |
| Di-Gata Defenders (USA) (En,Fr,Es) | |
| Diabolik - The Original Sin (Europe) (En,Fr,De,Es,It,Nl) | |
| Diary Girl (USA) | |
| Diddl Puzzle - Echter Puzzlespass fuer Unterwegs (Europe) (En,Fr,De,Es,It) | |
| Diddy Kong Racing DS (Europe) (En,Fr,De,Es,It) | |
| Diddy Kong Racing DS (USA) | |
| Diego's Build and Rescue (Europe) (En,Fr,Nl) | |
| Diego's Build and Rescue (USA) | |