| Doctor Who (Europe) | |
| Dodge Racing - Charger vs Challenger (USA) (En,Fr,Es) | |
| Dogz (Europe) | |
| Dogz (Europe) (En,Fr,De,Es,It) | |
| Dogz (USA) | |
| Dogz 2 (Europe) (En,Fr,De,Es,It) | |
| Dokapon Journey (USA) | |
| Dokapon Journey! - Nakayoku Kenka Shite (Japan) | |
| Doki Doki Majo Shinpan Duo (Japan) | |
| Doki Doki Majo Shinpan! (Japan) | |
| Doki Majo Plus (Japan) | |
| Dokodemo Pilates (Japan) | |
| Dokodemo Raku Raku! - DS Kakeibo (Japan) | |
| Dokodemo Yoga (Japan) | |
| Dokonjou Shougakusei Bon Biita - Hadaka no Choujou Ketsusen!! - Biita vs Dokuro Dei! (Japan) | |
| Dolphin Island - Underwater Adventures (Europe) (En,Fr,De,Es,It,Nl) (NDSi Enhanced) | |
| Dolphin Island (Europe) (En,Fr,De,Es,It,Nl) | |
| Dolphin Trainer (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| Don Bluth Presents - Dragon's Lair (USA) | |
| Don King Boxing (Europe) (En,Fr,De,Es,It) | |
| Don King Boxing (USA) (En,Fr,De,Es,It) | |
| Dondake Sports 101 (Japan) | |
| Donkey Kong - Jungle Climber (Europe) (En,Fr,De,Es,It) | |
| Donkey Kong - Jungle Climber (Japan) | |
| Donkey Kong in Super Mario 64 DS | |
| Donkey Xote (Europe) (En,Fr,De,Es,It) | |
| Doodle Hex (Europe) (En,Fr,De,Es,It) | |
| Dora & Friends' - Fantastic Flight (Europe) | |
| Dora & Friends' - Pet Shelter (Europe) (En,Fr,Es,Nl) | |
| Dora & Kai-Lan's Pet Shelter (USA) | |
| Dora Puppy (USA) | |
| Dora the Explorer - Dora Puppy (Europe) | |
| Dora the Explorer - Dora Saves the Mermaids (Europe) | |
| Dora the Explorer - Dora Saves the Mermaids (Europe) (En,Fr,De,Nl) | |
| Dora the Explorer - Dora Saves the Mermaids (Europe) (Sv,No,Da,Fi) | |
| Dora the Explorer - Dora Saves the Mermaids (USA) | |
| Dora the Explorer - Dora Saves the Snow Princess (Europe) | |
| Dora the Explorer - Dora Saves the Snow Princess (Europe) (En,Fr,Nl) | |
| Dora the Explorer - Dora Saves the Snow Princess (USA) | |
| Dora's Big Birthday Adventure (Europe) (En,Fr,Nl) | |
| Dora's Big Birthday Adventure (USA) | |
| Dora's Cooking Club (Europe) (En,Fr,Nl) | |
| Dora's Cooking Club (USA) | |
| Dorabase - Doraemon Super Baseball Gaiden - Dramatic Stadium (Japan) | |
| Dorabase 2 - Nettou Ultra Stadium (Japan) | |
| Doraemon - Nobita no Kyouryuu 2006 DS (Japan) | |
| Doraemon - Nobita no Shin Makai Daibouken DS (Japan) | |
| Doraemon - Nobita to Midori no Kyojinden DS (Japan) | |
| Double Sequence - The Q-Virus Invasion (Europe) (En,Fr,De,Es,It) | |
| Double Sequence - The Q-Virus Invasion (USA) (En,Fr,De,Es,It) | |